The Pistoia Alliance brings together the biopharmaceutical ecosystem, powering collaboration to drive innovation and new breakthroughs.
Our global community of more than 200 member organizations from across the biopharma ecosystem collaborates to solve common problems, sharing expertise and R&D costs, to move the industry forwards and ensure better outcomes for all.
Become a Member2025-2026 Pistoia Alliance Annual Report
This report captures the IMPACT the Alliance has on its members and the wider Life Sciences industry.
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A NEW IDEA FOR HELM
Shape the next chapter of HELM
HELM is a widely adopted notation for complex biomolecules. As its use has spread, challenges have emerged, from ambiguities in the specification to representing glycans and bioconjugates. A new idea proposes a community-driven update. If your work relies on HELM, help shape what comes next.
Visit the idea webpage
VERSION 1.1 OF THE CMC PROCESS ONTOLOGY
A more consistent shared language for pharma manufacturing
Version 1.1.0 of the CMC Process Ontology is now available to Pistoia Alliance members. This release focuses on quality: validation work, stakeholder feedback and issues raised on GitHub have made the ontology more consistent, more interoperable and easier to maintain. Metadata and annotations are standardized. Terminology and definitions are refined, and identifiers and imports corrected. The ontology is also aligned with releases of external ontologies, and imported terms carry more detail on provenance.
Visit project webpage
WHAT HAVE WE BUILT TOGETHER?
The whole portfolio on one page
The Project & Community Roadmap puts every Pistoia Alliance project and community on a single timeline. 26 initiatives, 107 actions, from early 2025 through early 2027. Search it, filter it by theme or status, and follow any deliverable straight through to the output. The content shows what is happening, what is shipped, and what is coming next.
Explore the roadmap
WHAT ROLE SHOULD AI PLAY?
Designing AI's role, not just explaining its decisions
AI is quietly appearing across enterprise tools, framed as a helpful colleague. But do we really know what it's there to do? In the first article of a UXLS series on AI, Stijn Janssen (Novo Nordisk) argues the harder challenge isn't explaining how AI decides, but designing the role it plays. And he proposes how to think about it. Don't miss it!
Read the article
SOCIAL MEDIA AS REAL-WORLD EVIDENCE
Making the patient voice count in drug development
In a new Clinical Leader interview, Pistoia Alliance project leaders Thierry Escudier and Aditya Tyagi discuss how social media listening captures the patient voice, reaching larger, more diverse populations. They share thoughts on patient openness, regulatory perspectives, and how social media can be a credible, structured source of real-world evidence.
Read the interview
